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Development of Electrochemiluminecence Sensor for Verapamil Hydrochloride Based on TiO2 sol/ZnO@Ag/Silica sol-Ru(bpy)32+ Modified Pyrolytic Graphite Electrode (Supporting Information)

posted on 29.06.2022, 01:08 authored by Ying LUO, Yingshi HUANG, Yanqing LI, Jun FENG

A sensitive solid-state electrochemiluminesence (ECL) sensor for verapamil hydrochloride (VpCl) was fabricated based on the film formability of TiO2 sol and electrocatalysis of ZnO@Ag. The immobilization of tris(2, 2′-bipyridine) ruthenium (II) (Ru(bpy)32+) by using TiO2 sol/ZnO@Ag/silica sol composite exhibited stable ECL behaviors, and a sensitive and selective method was developed for VpCl determination. Under the optimal conditions, the ECL response of the sensor showed a linear correlation to the concentration of VpCl in the range of 1.0 × 10−7–1.0 × 10−4 mol L−1 (R2 = 0.9832) with a detection limit of 7.00 × 10−9 mol L−1 (S/N = 3). The RSD of ECL response was 2.07 % for 1.0 × 10−5 mol L−1 VpCl under 10 continuous cyclic scans. The spiked recovery was 97.90–104.50 % for determination of real VpCl sample. The proposed method exhibited selectivity and sensitivity for VpCl, and improved efficiency of Ru(bpy)32+.


Natural Science Foundation of Guangxi Province

Construction of Functionalized Nanocomposite hCEs SERS Probes and Their Application in the Detection of Carboxylesterase Activity in Serum and Cells

National Natural Science Foundation of China

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